Carol Fabian

Publish date: 2024-06-24

Research

Overview

Dr. Fabian’s early research was primarily in breast cancer treatment but for the past 25 years the research focus has been primarily in breast cancer prevention and survivorship. Currently her clinic practice is confined to breast cancer risk assessment and which includes genetic testing, and prevention. Prevention encompasses advice on supplemental screening, lifestyle, hormone replacement and alternatives, and standard and clinical trial approaches to risk reduction. Dr. Fabian and her team have focused on evaluating prevention interventions which are likely to be effective but unlikely to negatively impact quality of life. Recently these have including for premenopausal women lignans, omega-3 fatty acids, and novel selective estrogen receptor modulators, and for postmenopausal women tissue selective estrogen complexes, omega-3 fatty acids, and behavioral weight loss interventions. She developed a minimally invasive technique for sampling benign breast tissue called random periareolar fine needle aspiration (RPFNA) which has subsequently been used by multiple investigators in early phase prevention clinical trials to assess gene and protein expression changes with the intervention. The biomarker investigational work and translational early phase trials have been supported by our ~$20 million in federal and $3 million in foundation direct cost funding for which Dr. Fabian was PI. She has ~ 167 peer-reviewed manuscripts plus invited reviews editorials and book chapters. A full listing is available in MyBibliography: http://www.ncbi.nlm.nih.gov/myncbi/browse/collection/47845155/.

National Research Service
Dr. Fabian currently serves as the site PI and on the executive committees of two NCI funded Early Clinical Prevention Trial Consortia, (Northwestern and University of Michigan) with her primary aim of mentoring young clinicians to develop and conduct Phase I and II prevention trials. She is a Fellow of the American Society of Clinical Oncology. She has previously co-chaired the SWOG Cancer Survivorship committee, chaired ASCO’s Prevention committee, and the Prevention Workforce Pipeline, co-chaired ASCO’s Pharmacologic Interventions for Breast Cancer Risk Reduction (2019), and served on ASCOs committees which developed Position Statements on Obesity, as well as Prevention and Monitoring of Cardiac Dysfunction in Cancer Survivors. She is currently a Fellow of the American Society of Clinical Oncology.

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